(:source 
  :version  5
  :ip-address "137.132.3.3"
  :ip-name "solomon.technet.sg"
  :tcp-port 210
  :database-name "prosite"
  :cost 0.00 
  :cost-unit :free 
  :maintainer "waisguy@solomon.technet.sg"
  :description "
Server created with WAIS release 8 b5 on 
Dec  7 19:50:37 1992 by waisguy@solomon.technet.sg

The files of type dash used in the index were:
	 /home/waisguy/src/prosite-db

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	PROSITE: A DICTIONARY OF PROTEIN SITES AND PATTERNS
			 USER MANUAL
		Release 9.10, August 1992

	Amos Bairoch
	Medical Biochemistry Department
	Centre Medical Universitaire
	1211 Geneva 4
	Switzerland

	Telephone: (+41 22) 361 84 92
	Electronic mail address: bairoch@cgecmu51.bitnet
			or bairoch@cmu.unige.ch

The use  of  protein  sequence  patterns  (or  motifs)  to  determine  the
function(s) of  proteins is  becoming very  rapidly one  of the  essential
tools of  sequence analysis.  This reality  has been  recognized  by  many
authors including well known  experts ofprotein sequence analysis, R.F. 
Doolittle and A.M. Lesk.

PROSITE is a compilation of sites and patterns found in protein sequences.
Some of  these patterns been published in the literature, but the majority
have been developed, in the last two years, by the author. Originally this
dictionary was  conceived as part of the author's doctoral dissertation as
well as  an integral  part of  the PROSITE program in the PC/Gene sequence
analysis software  package. But,  as  many  people  have  expressed  their
interest in  this project,  we have decided to make this work available on
computer media as well as in a printed form.

If you want to refer to PROSITE in a publication you can do so by citing:

	 Bairoch A.
	 PROSITE: a dictionary of sites and patterns in proteins.
	 Nucleic Acids Res. 19:2241-2245(1991).

This release of PROSITE  contains 580  documentation  entries  that describe
689 different patterns including:

Post-translational modificationsElectron transport proteins
Domains Other transport proteins
DNA or RNA associated proteins  Structural proteins
Enzymes Receptors
	 Oxidoreductases  Cytokines and growth factors
	 Transferases  Hormones and active peptides
	 Hydrolases Toxins
	 Lyases  Inhibitors
	 Isomerases Others
	 Ligases
	 Other Enzymes

This WAIS source of the PROSITE dictionary has been created with the 
permission of Dr Amos Bairoch by Dr Tin Wee TAN, Dept of Biochemistry,
(INTERNET: bchtantw@nuscc.nus.sg BITNET: bchtantw@nusvm.bitnet) and
Dr Derek Kiong, Dept of Information Systems and Computer Science 
(isckbk@nuscc.nus.sg) National University of Singapore, Kent Ridge,
Singapore 0511, and maintained on the Singapore TECHNET Unix at
solomon.technet.sg (137.132.3.3).

Newcomers are advised to use the keywords 'PROSITE' or 'help' or
'documentation' to find out more about the PROSITE dictionary. (Please
see the section below on  'Additional Hints'.)

For a list of where you can obtain the PROSITE database, please use
the keywords 'obtain' or 'get'.

For a list of software/programs that make use of PROSITE, please use
the keywords 'software' or 'program'.

For a detailed explanation of how this source was indexed, use the
keyword 'WAISINDEX' to retrieve the entry or consult
bchtantw@nuscc.nus.sg or isckbk@nuscc.nus.sg. Comments are warmly
welcomed.

For questions relating to the content of the PROSITE dictionary,
you are requested to direct your queries to the copyright author
of PROSITE, Dr Amos Bairoch (address given above).

The entire database or entries within the database may be copied and 
redistributed freely, without advance permission, provided that its
textual content is not modified.

ADDITIONAL HINTS for getting the best out of this WAIS service.
_______________________________________________________________

1) Use as wide a term for an initial search. Eg if looking for
	 chymotrypsin, start with protease.  
2) Be careful when using the PDOC numbers. Note that the O is not the
	 same as 0.
3) Because of the indexing software, keyword chymotrypsin may not
	 pick up entries without the exact word chymotrypsin, even though
	 the word chymotrypsins may be present.
4) To understand the way the way the entries are structured, read the
	 PROSITE documentation (keywords PROSITE documentation help).
"
)
